Ko te konutai Sulfadiazine he paturopi sulfonamide mahi-waenganui e whai hua ana ki te maha o nga huakita Gram-positive me Gram-negative. He hua antibacterial i runga i te Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella, Neisseria gonorrhoeae, Neisseria meningitidis, me Haemophilus influenzae. I tua atu, he kaha ano ki a Chlamydia trachomatis, Nocardia asteroides, Plasmodium, me Toxoplasma in vitro. Ko te mahi antibacterial o tenei hua he rite ki te sulfamethoxazole. Heoi, i nga tau tata nei, kua piki ake te aukati huakita ki tenei hua, ina koa ko Streptococcus, Neisseria, me Enterobacteriaceae.